Science and Technology
publicado em 19/04/2011 às 13h40:00
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Brazilian researchers develop three-dimensional model of human tooth

Researchers have used computer graphics to fabricate three-dimensional structures of tooth proportions faithful

 
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Foto: Silvio Duailibi
Faithful reproduction of human teeth by means of additive fabrication process, a technique that uses computer models
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Faithful reproduction of human teeth by means of additive fabrication process, a technique that uses computer models

The dentists and Monica Silvio Duailibi Unifesp teachers, took the first step in a faithful reproduction of human teeth by means of additive fabrication process, a technique that uses computer models. The study was developed in partnership with the Center for Information Technology Renato Archer, research agency of the Ministry of Science and Technology.

The additive fabrication, also known as rapid prototyping, enables to produce prototypes directly from three-dimensional virtual model based on data obtained from CT scans or MRIs. The research was published this year in the journal American Artificial Organ.

Biodegradable material, the structure of the molars generated by 3D technique is already being tested by researchers in the so-called pre-clinical, with the cultivation of human adult stem cells in rats. Previously, we have developed crowns with all its structures, such as dentin, enamel, pulp and periodontal ligament in the jaw and abdomen of animals, but their size and shape were not of a normal tooth, explains Duailibi Silvio, who is associate professor of Biomedical Engineering Institute of Science and Technology of UNIFESP in Sao Jose dos Campos.

To Duailibi Monica, a professor of the discipline of Plastic Surgery, Escola Paulista de Medicina, UNIFESP, reproduction of these structures, true to size and shape of human teeth, and use of human cells also marks another step toward third dentition.

In 2004, the couple of researchers who are also researchers at the Centre for Cellular and Molecular Therapy (CTCmol) of the University, succeeded in making dental crowns in the abdomen of mice by means of Tissue Engineering and four years later, to make the crowns are develop in the jaws of animals from adult stem cells extracted from teeth of the same species.

The study - which is co-author Lydia Masako Ferreira, professor of the discipline of Plastic Surgery, UNIFESP, Eduardo Felippe Duailibi Neto, Master in Oral Diagnosis of the FO-USP, Waldyr Antonio Jorge, professor of FO-USP, Renata Matalon Negreiros, the Fundecto - had the supervision and collaboration of U.S. researchers Pamela C. Yelick, Tufts University, and Joseph P. Vacanti, Massachusetts General Hospital and Harvard Medical School.

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Search for ideal biomaterials

To have the regeneration of calcified structures of human teeth, Silvio Duailibi explains the need to find the ideal biomaterial for the construction of structures that will receive stem cells. Several biocompatible materials and are degraded by the body are under consideration, he says.

According to Silvio Duailibi, obtaining that component to the interaction of stem cells and the certainty that these cells are stable and do not turn into tumors, the next step is to begin studies in humans. However, we still lack a term to initiate these tests.

The survey, which was financed by the Fund for Research Support of São Paulo (FAPESP) and the National Institutes of Health (NIH), U.S., has a partnership with the National Institute of Biomanufacturing (Biofactory), the Ibero American Cyted of Biomanufacturing Center and Information Technology Renato Archer (CTI), responsible for developing the system prototyping in medicine.

We also collaborate with the study, researchers George Esper Kallas (USP), Monica Lipay Vanucci (UNIFESP), Jorge Vicente Lopes da Silva (CTI) and Israel Chilvarquer (FOR - USP).

Source: UNIFESP
   Palavras-chave:   Tooth    Three-dimensional    UNIFESP. Reproduction    Computer Graphics   
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