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publicado em 01/04/2011 às 03h00:00
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Genetic defect suggests that high blood pressure is inherited from the mother

Single mutation in the mitochondria may provide new insights into the 'transmission' of maternal hypertension

 
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Specific genetic defect discovered in a Chinese family revealed that high blood pressure may be inherited from the mother. The discovery by researchers from Cincinnati Children's Hospital Medical Center, the United States and the Medical University of Vienna, Austria.

The defect is the result of a single mutation - the substitution of one DNA base for another during replication - in the genes of a small cellular organelles called mitochondria, which generates energy for the cell.

When reproductive cells join to form an embryo, the cell's mitochondrial DNA is passed from mother to children. Evidence has suggested a link between high blood pressure inheritance from his mother due to mitochondrial inheritance.

Results of the study provide genetic evidence, molecular and biochemical characteristics of a mitochondrial mutation known as tRNAIle 4263A> G is associated with inheritance of high blood pressure.

Geneticists have identified a large family from northern China where 15 of the 27 members who descend from the same ancestral females had blood pressure above 140/90 mmHg, even after treatment. Only seven of 81 non-maternal relatives had high blood pressure.

The researchers compared family members with 342 Chinese residents in the same area to confirm a maternal bond. The analysis of the mitochondrial genome of maternal relatives and other tests revealed the location of the mutation linked to hypertension and showed that this mutation affect the mitochondrial respiratory chain, which increases levels of reactive oxygen species (ie free radicals).

Results show that mitochondrial dysfunction is involved in inherited high blood pressure and may provide new insights on the heritability of maternal hypertension.

Source: Isaude.net
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