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publicado em 31/03/2011 às 03h00:00
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New agents improves healing of chronic wounds healing

New approach may mean healing process faster and better adapted to the needs of individual patients

 
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Researchers from Tufts University in the United States, are developing a new class of agents that accelerate the healing blood vessel growth to improve healing of acute and chronic wounds.

New approach may mean healing process faster and better adapted to the needs of individual patients.

Accelerating recovery

The study leader, Ira Herman and his team used the natural healing process as a model for its new approach.

In a typical wound healing as well, the growth of new blood vessels at the injury site, a process called angiogenesis, is a critical first step. These new capillaries and blood vessels bring oxygen and nutrients needed to build new tissue.

But for the occurrence of angiogenesis, cells that give rise to new vessels should be capable of migrating to and from the around the injury site. At the beginning of 1990 Herman found that collagenase, an enzyme produced by the bacterium Clostridium histolyticum, accelerates the healing of wounds, allowing the cells to migrate many times faster in tissue culture.

The main objective of the enzyme is to digest, or break, collagen, a key component of skin and other tissues in the wound. Collagenase, which humans also produce, cut the collagen molecules into fragments of proteins called peptides. Versions in bacteria and humans, however, cut the collagen slightly differently, leading to different peptides.

Herman reasoned that bacterial collagenase may give rise to peptides that could offer an advantage to promote healing. He and his colleagues began to test this hypothesis.

Healing custom

To test this idea, Herman and his colleagues began treating models of cellular and animal tissue with enzymes, peptides or control substances produced by bacterial action of collagenase.

Although some protein fragments were produced by both human and bacterial collagenases, scientists have isolated more than 10 different peptides that were unique to bacterial enzymatic activity. The team then sequenced peptides of specific bacteria to determine their chemical structures.

Armed with this new knowledge, the team was able to combine components of specific peptide produced by the bacterial enzyme to create synthetic peptides capable of stimulating the growth of blood vessels and improve wound healing.

To demonstrate the ability of these peptides healing experiments, scientists have created models of wounds grouping layers of animal cells and tissue components, wounding them with a blunt needle. When they added synthetic peptides to mimic the healing process, the peptides actually increased the speed of wound healing models, including angiogenesis.

This new class of custom synthetic peptides may one day become an integral part of emergency medicine. Prompt treatment can reduce healing time and minimize the pain and suffering of patients.

France

Source: Isaude.net
   Palavras-chave:   Wound healing    Healing agents    Tufts University    Ira Herman   
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