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publicado em 21/02/2011 às 03h00:00
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Scientists enhance effectiveness of the vaccine used against tuberculosis

"Our vaccine is more effective because it is quickly recognized by the vaccinated person's immune system"

 
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Researchers at the Institute of Pesqusia VIB in Belgium have discovered a new way to improve the effectiveness of the vaccine currently used against tuberculosis (TB).

Led by researchers and Nico Callewaert Festjens In it, the research team has shown in rats that the new vaccine provides better protection against disease.

"Our vaccine is more effective because it is quickly recognized by the vaccinated person's immune system. We undressed, so to speak, the existing vaccine, eliminating their protection," said Callewaert.

The treatment of tuberculosis are also very expensive and difficult because of multidrug resistant tuberculosis. Therefore, there was a strong emphasis on vaccination as a weapon against the disease.

The only vaccine on the market is Bacille Calmette-Guerin (BCG). It is produced from bacteria live bovine tuberculosis, Mycobacterium bovis, which lost its virulence in humans. In children, the vaccine prevents only half of tuberculosis cases in adolescents and adults and the degree of protection is even lower.

In recent years, several other vaccines have been developed and some of these have been tested in humans. Only a few have led to a moderate improvement in protection compared with BCG. The search for a more effective vaccine is therefore continuous.

New approach

The bacterium from which the vaccine is derived lurks as a part of the body's immune system when it is introduced. This may be the reason why the vaccine is not very effective. The fact is that a vaccine intended to stimulate an immune response in order to be able to afford good protection. Nico Callewaert Festjens Him and found that the bacterium lies behind SAPM enzyme that acts as a shield.

They used this knowledge to develop a new vaccine. They adapted Mycobacterium bovis BCG in a way that she was not able to generate SAPM and could not therefore hide from the immune system.

Tests of the new vaccine in mice showed that it provides better protection than the current BCG vaccine.

Mechanism different

The researchers also demonstrated that its vaccine works differently from other vaccines being tested.

In fact, it acquires its value by issuing extra protection signals that trigger inflammation and thereby activate the immune cells. Festjens Callewaert and are convinced that the implementation of its strategy to remove the protective shield - the new vaccines that are a little better than the vaccine currently being marketed, should lead to a vaccine that offers real protection against tuberculosis.

Source: Isaude.net
   Palavras-chave:   Tuberculosis vaccine    BCG    Instituto de Pesqusia VIB   
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