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publicado em 12/01/2011 às 16h00:00
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Antagonist of growth hormone can have effects suffers aging

Results are significant because people believe that growth hormone is the fountain of youth

 
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Foto: Steve Dolan
John E. Morley, co-investigador do estudo e diretor das divisões de geriatria e endocrinologia em Saint Louis
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John E. Morley, co-investigador do estudo e diretor das divisões de geriatria e endocrinologia em Saint Louis

A substance that acts in the opposite direction of growth hormone can reverse some symptoms of aging, according to a research team that includes a physician at the University of Saint Louis.

The finding may be counterintuitive to some older adults who take growth hormone, thinking that will help prevent aging.

The research was published in the journal Proceedings of the National Academy of Sciences.

The results are significant, says John E. Morley, co-investigator of the study and director of the division of geriatrics and endocrinology at Saint Louis, because people sometimes take growth hormone believed to be the fountain of youth.

"Many seniors have taken growth hormone to rejuvenate," said Morley. "These results strongly suggest that growth hormone, when administered to middle-aged and elderly, can be dangerous."

The scientists studied the compound MZ-5-156, an antagonist of the hormone releasing hormone (GHRH). They conducted their research in the mouse model SAMP8, a strain engineering for studies of the aging process.

In general, the researchers found that MZ-5-156 had positive effects on oxidative stress in the brain, improving cognition, telomerase activity (the actions of an enzyme that protects the DNA material) and length of life and decreasing the tumor activity.

The MZ-5-156, like many GHRH antagonists inhibited several human cancers, including prostate, breast, brain and lung. He also had positive effects on learning and is linked to improved short-term memory. The antioxidant properties led to less oxidative stress, reversing the loss of cognitive aging in mice.

Source: Isaude.net
   Palavras-chave:   Growth hormone    Aging    Geriatrics    MZ-5-156    GHRH   
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