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publicado em 27/12/2010 às 02h00:00
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Researchers discover how natural drug helps fight inflammation

Results reveal new therapeutic targets in developing treatments for inflammatory and autoimmune

 
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Researchers at Virginia Polytechnic Institute and State University, U.S., discovered as abscisic acid, a natural plant hormone with known beneficial properties for the treatment of diseases, helps combat inflammation. The results reveal new therapeutic targets for developing treatments for inflammatory and autoimmune diseases.

The research team revealed the mechanism by which abscisic acid interacts with a protein known as receptor activated by peroxisome proliferator Gama, to block the inflammation and the subsequent appearance of disease.

"In previous work, our research group showed that abscisic acid has beneficial effects in various conditions and diseases including inflammation related to obesity, diabetes, atherosclerosis and inflammatory bowel disease," said lead researcher Josep Bassaganya-Riera. "An idea of how the abscisic acid reduces inflammation in these cases is that it binds to a particular region of the proliferator activated receptors Peroxisome Gama, a binding site known as the ligand binding domain, where the drug exerts its effect. Our results show that this is not the case and for the first time, we show that abscisic acid functions independently of ligand receptor binding domain. "

The researchers believe that this new information is important because it suggests the existence of new therapeutic targets or alternative modes of action for the effects of abscisic acid on the immune system.

Results also showed that the alternative mechanism recently discovered, there appears to be linked to any known adverse side effect, which represents a promising new therapeutic path.

"These results illustrate the synergy that can result from a combination of computational and experimental approaches for the characterization of therapeutic targets," said associate professor of biochemistry at Virginia Tech, David Bevan. "Through molecular modeling approaches, we identified a potential site for abscisic acid binding to the lanthionine synthetase C-2, a protein necessary for the beneficial effects of abscisic acid. We were also able to reveal reasons for the lack of direct association of abscisic acid Activated Receptor with Peroxisome Proliferator of Range. "

The lanthionine synthetase C-2 represents the first step in a path that leads to activation of the receptor activated by peroxisome proliferator Gama in the immune system by abscisic acid.

"We have also shown that abscisic acid affects the expression of many genes involved in metabolism of inflammation and cell signaling, which provides new clues to possible points of intervention in the treatment of inflammatory and autoimmune diseases," said one of the authors Raquel Hontecillas.

The researchers hope to identify more closely at some of the new drug targets in the molecular network of the immune response, and continue to dissect the manner by which abscisic acid reduces damage due to inflammation.

Moreover, the understanding of how it works abscisic acid is used to develop a potentially safer approach.

Source: Isaude.net
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Abscisic acid    inflammation    autoimmune diseases    Josep Bassaganya-Riera    Virginia Polytechnic Institute and State University   
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