Science and Technology
publicado em 24/12/2010 às 17h40:00
   Dê o seu voto:

Protein helps to understand the fly's birth defects in humans

Half of the genes known to cause disease in humans have their counterpart in the genetic code of the fruit fly

 
font size
A-
A+

Some pieces of information on this page may have been automatically translated. Makernews is not responsible for the irregularities resulting from these translations. When in doubt,      consult the original text.



Using fruit flies as a model for studying the formation of human embryos, scientists at Cincinnati Children's Hospital Medical Center, USA, reported that the breaking of a molecular protein called Bicoid is critical to the standardization of head-tail normal offspring of the insect.

The study shows how Bicoid is a target of molecular degradation by a newly identified protein called Fates-shifted (DSF). Without the interaction between Bicoid and FSD, the fruit fly embryos become deformed. The results are one more example of how molecular and genetic studies of embryonic development in fruit flies help to inform medical research on human disease and birth defects. More than half of the genes known to cause disease in humans have a recognizable match in the genetic code of the fruit fly.

"Although there is no direct medical impact, this study has critical importance for medical research in birth defects," said senior researcher, Jun Ma "For the tissues in the developing embryo to form properly, cells have to know what are their proper locations. This study analyzes the location of clues that the cells receive in Drosophila embryos. "

The clues are delivered through a process scientists still do not fully understand. It is controlled by molecules called morphogens, which form concentration gradients along the axis of head-tail, or other axes of developing embryos. Scientists think that these gradients allow the cells know their location when they evaluate whether the chemical signals they receive are above or below specific thresholds. The knowledge of the cells of their position leads them to choose different development paths and to form different types of embryonic tissues.

"There are really two sides of MorphoGen problem," Ma said "The first is how concentration gradients are formed first and the second is how cells respond to such a gradient. Our study examines the first question at a molecular level."

Bicoid is a protein essential to embryonic fruit fly in the formation of the head and chest. The new findings suggest that the molecular breakdown of protein is important for establishing a concentration gradient and the correct formation of adequate tissue in their correct locations within the embryo.

France

Source: Isaude.net
   Palavras-chave:   Fruit fly    Birth defects    Bicoid    Jun Ma    Cincinnati Children's Hospital Medical Center   
  • Share this pageShare this page
  • Share this pageCorrect
  • ShareShare
  • AlertAlert
Reduced link: 
  • You are recommending this story: Protein helps to understand the fly's birth defects in humans
  • Fill in the following form to send your recommendation to your friend:

  • You are suggesting a correction for this story: Protein helps to understand the fly's birth defects in humans


Receba notícias do iSaúde no seu e-mail de acordo com os assuntos de seu interesse.
Seu nome:
Seu email:
Desejo receber um alerta com estes assuntos:
fruit fly    birth defects    Bicoid    Jun Ma    Cincinnati Children's Hospital Medical Center   
Comments:
Comment
Leave your comment
Close
(Required fields are marked with an *)

(Your email address will never be published or shared.)

Enter the letters and numbers below and click in the button "send"

  • Twitter iSaúde
advertising
Informe Saúde printed version

Recommend the portal
Close [X]
  • You are recommending this story: http://www.isaude.net
  • Fill in the following form to send your recommendation to your friend:

RSS news from the portal  iSaúde.net
Get the newsletter of the portal  iSaúde.net
Recommend the portal iSaúde.net
News from  iSaúde.net in your blog or website.
Get news on the subject of your interest.
© 2000-2011 www.isaude.net Todos os direitos reservados.