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publicado em 09/09/2010 às 22h00:00
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Insulin may reduce inflammatory factors in patients in intensive care

Results showed that insulin reduced the risk of inflammation and oxidative stress in patients enrolled in the study

 
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Foto: Divulgação / Univ. de Buffalo
Paresh Dandona demonstrated that treatment with insulin can reduce the chances of succumbing to an infection
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Paresh Dandona demonstrated that treatment with insulin can reduce the chances of succumbing to an infection

A study by the University of Buffalo showed that insulin can reduce a number of inflammatory factors induced by bacterial infection and sepsis in patients undergoing intensive therapy.

The results showed that insulin reduced the risk of inflammation and oxidative stress in patients enrolled in the study who were injected with a common bacterium, or endotoxin, known as LPS (lipopolysaccharide).

The LPS, found in the outer membrane of various Gram-negative bacteria, is known to increase the ability of bacteria to cause hemorrhage, necrosis of the kidneys and shock, especially in immunocompromised patients.

The study involved 19 healthy volunteers who were injected with a dose of endotoxin based on its weight. After injection of endotoxin, 10 participants were infused with insulin (plus dextrose to maintain normal glucose levels) and nine received a saline solution to mimic the insulin infusion.

The researchers monitored the temperature, pulse, blood pressure, headaches, body aches and chills of the volunteers during 24 hours after injection of endotoxin. Blood samples were collected one hour before the injection, the time of injection and one, two, four, six and 24 hours later.

The monitoring showed that endotoxin increased body temperature by three degrees - from 98 to a peak of 101.3 in the mark of four hours and produced body aches and headaches, one to two hours. The results showed that insulin reduced the score and body aches. However, had no effect on the temperature.

Furthermore, endotoxin induced a rapid rise of several inflammatory and destructive factors, including reactive oxygen species (free radicals) and products of nitric oxide, in addition to fat metabolism. Insulin infusion led to total elimination of several pro-inflammatory factors and a significant reduction in the generation of reactive oxygen species and products of fat metabolism.

Paresh Dandona, professor of medicine and senior author of the study, said this study confirms the expectations on the anti-inflammatory effect of insulin. "This study lays the groundwork for further study based on insulin infusion and normalization of blood glucose concentrations in patients with endotoxemia and sepsis.

The group demonstrated that insulin also has anti-inflammatory and cardioprotective in patients who had a heart attack, and currently is conducting a study on the potential beneficial effects of insulin on acute stroke.

"Clearly, insulin may play roles other than those designed when it was discovered in 1921 as a metabolic hormone, and has since been used to treat diabetes and to reduce glucose concentrations in blood," concludes Dandona.

France

Source: Isaude.net
   Palavras-chave:   Insulin    Antibacterial    Sepsis    Infection    Intensive care    Dextrose    Dextrose    Endotoxin   
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