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publicado em 08/09/2010 às 16h00:00
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Prototype implantable artificial kidney dialysis to replace already in test

The device has microscopic filters, and a bioreactor that mimics the metabolic balance and the role of real water kidney

 
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Foto: Divulgação/UCSF
Foto: Divulgação/UCSF
Foto: Divulgação/UCSF
Shuvo Roy, Department of Bioengineering and Therapeutic Sciences at UCSF. Illustration of the model of implantable bioartificial kidney shows the two-phase system The device will use thousands of nanoscale filters to remove toxins from the blood
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Shuvo Roy, Department of Bioengineering and Therapeutic Sciences at UCSF.
Illustration of the model of implantable bioartificial kidney shows the two-phase system
The device will use thousands of nanoscale filters to remove toxins from the blood

A University of California (UCSF) in San Francisco, unveiled the prototype of the first implantable artificial kidney in development. The discovery may in the future, eliminating the need for dialysis.

The device - which has thousands of microscopic filters, and a bioreactor to mimic the metabolic balance and the role of water in a real kidney - is being developed through a partnership between engineers, biologists and physicians across the country, led by Shuvo Roy, Department of Bioengineering and Therapeutic Sciences at UCSF.

The team's objective is to apply the manufacturing technology of silicon, with compartments designed for the living kidney cells in order to develop smaller devices on a large scale that would be implanted in the body without the use of immunosuppressive drugs. This should enable the patient to have a normal life.

"This device is designed to provide the most benefit from a kidney transplant, given the small number of kidney donors per year," said Roy, School of Pharmacy at UCSF. "This can dramatically reduce the burden of renal failure in millions of people worldwide, in addition to reducing one of the biggest costs in health in the United States."

The team demonstrated the feasibility of a model implanted in animal models, so that human clinical trials may be undertaken in a maximum of five or seven years.

The final stage of renal disease or chronic kidney failure, affects over 500,000 people per year in the United States and currently only fully treated with a transplant kidney. Roy explains that this number has increased from 5% to 7% per year, in part because of kidney damage associated with diabetes and hypertension.

In addition, approximately 350 000 patients are dependent on kidney dialysis, which is costly for health and for the patient. A typical schedule is three dialysis sessions per week for three to five hours per session, in which blood is pumped through an external circuit to filter out. This is stressful for patients and replaces only 13% of renal function. As a result, only 35% of patients survive more than five years.

The device will utilize thousands of nanoscale filters to remove toxins from the blood. The system uses a hemofilter to remove toxins from the blood. The process is based on blood pressure of the body to perform filtering without the need for pumps or an electric power source.

The first phase of the project, once completed, has focused on developing the technologies needed to shrink the device to fit the body of animal models. Now the team is doing a sophisticated job, to raise the device for humans. The last step is to conduct clinical trials of the device.

France

Source: Isaude.net
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Comments:
Comment
Camillo Durval Berti
posted on:
04/04/2012 15:53:22
É urgente alguma nova terapia aos renais crônicos. O rim artificial seria o grande passo do século para diminuir e até eliminar as ¨pesadas¨diálises e até os riscos dos transplantes. Renal crônico, 70 anos de idade, há 5 anos em Hd, Advogado, vivo e presencio as ¨sacrificantes¨ terapias atuais!
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