Science and Technology

Study of USP combines antibiotics to fight hospital infections

30 combinations were developed. The combination polimedicina was chosen for testing in mice

Foto: Ministério da Saúde
Project can be an alternative for the prevention of complications in clinical internees
Project can be an alternative for the prevention of complications in clinical internees

Experiments conducted on mice showed that it is possible to combine different antibiotics to get more definitive results in the fight against hospital infections. The study, conducted at the Faculty of Pharmaceutical Sciences (FCF), USP, is an alternative to the use of drugs alone to combat this type of infection.

The idea came after the biomedical Micheli Medeiros noted that lack drugs effective against some types of bacteria. There are some varieties of which are multiresistant bacteria that have resistance to more than one antibiotic account. One reason for the rise of these superbugs is from the excessive and indiscriminate use of these drugs, says the researcher.

Were carried out a series of tests and combinations in the laboratory to the treatment against a type of bacteria called Acinetobacter baumannii, very common in hospitals and it has a high rate of drug resistance. They were developed in the laboratory, the screening phase, 30 different combinations of antibiotics. Of these, 14 had more satisfactory results. One of the combinations was chosen to proceed to the research.

In the second phase, mice, guinea pigs were divided into five groups, all of them showing a higher degree of infection. The first one had a saline injection. The second group was treated with the combination esolhida in the first phase of the study, polimedicina a concentration regarded as satisfactory. The third group received another dose of the antibiotic selected, the emipenem. A fourth group was treated with the combination of both antibiotics and the last group received no medication. We did a treatment for three days, injecting doses every 12 hours, describes Micheli.

The results showed that treatment separately, antibiotics showed no effective action against bacteria. Already in common use, the drugs worked satisfactorily and proved potentially effective.

Micheli studied the subject in the Master thesis with the title In vitro and in vivo synergistic effects of antibacterials for the treatment of multiresistant infections porAcinetobacter baumannii producing OXA type carbapenemase endemic in Brazil.

Application in human <b> <b>

Micheli believes the project has the potential to evolve to the stage of human trials, and that the next steps depend on a number of investments and medical approval for clinical use. According to it, the combined use of antibiotics has many benefits for the patient, eg by reducing the concentration of drugs used during the treatment.

The researcher emphasized that in some treatments, they use a very high amount of antibiotics, which contributes to increase toxicity in the body of patients. This ends up causing other health problems in the future, which can range from kidney complications until the commitment hearing. In this sense, the project ends up acting as an alternative for the prevention of clinical complications in the hospital, contributing to the control of infections within the hospital, complete.