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02.08.2012

Search USP explains the action of schistosomiasis to create new drugs

Study is helping in understanding the activity of a protein in the parasite that causes the disease, Schistosoma mansoni

Foto: Magnus Manske
The parasite Schistosoma mansoni, the enzyme has a function different from that exercise in man
The parasite Schistosoma mansoni, the enzyme has a function different from that exercise in man

New insights may contribute to the future development of drugs to combat esquistossomose. This is because results of a study developed at the University of São Paulo (USP) are helping to explain the action of a protein in the parasite that causes the disease, Schistosoma mansoni.

The parasite's main characteristic is the high egg-laying: about 300 a day, which also represents a major cellular activity. From this understanding, the researchers seek remedies that not only combat the parasite, but also take effect on the production of energy molecules and prevent egg laying. This type of combat to avoid recurrence of the disease by preventing the proliferation of new parasites and contamination constant environments in which people infected.

To be able energy to this position so high, he obviously needs to synthesize DNA, for eggs, and energetic molecules, since the metabolic activity is very high, says the researcher who led the study, biologist Juliana Torini Roberta de Souza.

According to the head researcher, Humberto D Muniz, there must be the difference between the enzymes of host and parasite to the drug does not cause adverse reactions or harmful to patients.

Despite the interesting results of this work is not the endpoint of the study on the enzymes of S. mansoni. Purinoma Project, coordinated by Muniz and D which includes the research aims at understanding the functioning of all 18 enzymes that are known to be present in the way of salvation of the parasite, for, he said, use them in our favor . We want to understand how really works this way and discover the most interesting of the enzyme is inhibited, the researcher says.

With information <i> USP </ i>

Source: Isaude.net